Anabasis articulata exerts an anti-arthritic effect on adjuvant-induced arthritis in rats

Anabasis articulata (AA) is commonly found in the Iraqi desert and is utilized in traditional medicine to cure kidney infections, eczema, fever, and diabetes. The paper aimed to identify the anti-arthritic impact of AA on arthritis models in rats. Complete Freund's Adjuvant (CFA) was used intra...

Full description

Saved in:
Bibliographic Details
Published in:Journal of advanced pharmaceutical technology and research 2022-10, Vol.13 (4), p.276-280
Main Authors: Abdulhusain, Zaid, Mahdi, Makarim, Abdulsahib, Waleed, Jasim, Layth
Format: Article
Language:English
Subjects:
adjuvant-induced arthritis
anabasis articulate
Animal models
Arthritis
Body weight
Diabetes mellitus
Eczema
Freund's adjuvant
Kidneys
Original
Vascular endothelial growth factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anabasis articulata (AA) is commonly found in the Iraqi desert and is utilized in traditional medicine to cure kidney infections, eczema, fever, and diabetes. The paper aimed to identify the anti-arthritic impact of AA on arthritis models in rats. Complete Freund's Adjuvant (CFA) was used intradermally (ID) for the induction of arthritis. The author classified animals into four groups randomly: The first group took normal saline (control), the second group received AA orally for 14 days before induction and continue 17 days after induction, the third group was induced by CFA and received normal saline orally (model group), and the fourth group took AA orally 17 days after induction. AA administration increased body weight (BW) but decreased arthritis index (AI), histopathological scores, and vascular endothelial growth factor expression in synovial cells. AA has an important antiangiogenesis and anti-arthritic activity in arthritis model rats.
ISSN:2231-4040
0976-2094
DOI:10.4103/japtr.japtr_440_22