Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifunga...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2022-07, Vol.12 (7), p.1010
Main Authors: Fifere, Adrian, Turin-Moleavin, Ioana-Andreea, Rosca, Irina
Format: Article
Language:English
Subjects:
Antibacterial activity
Antibiotics
antifungals
Bacterial infections
Chemotherapy
Communication
Disks
Drug development
Drug resistance
E coli
Escherichia coli
Fungicides
Herbal medicine
increased activity
Levofloxacin
Nosocomial infection
Nosocomial infections
Protocatechuic acid
Pseudomonas aeruginosa
Staphylococcus aureus
Variance analysis
Yeasts
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Summary:The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12071010