Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifunga...

Full description

Saved in:
Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2022-07, Vol.12 (7), p.1010
Main Authors: Fifere, Adrian, Turin-Moleavin, Ioana-Andreea, Rosca, Irina
Format: Article
Language:English
Subjects:
Antibacterial activity
Antibiotics
antifungals
Bacterial infections
Chemotherapy
Communication
Disks
Drug development
Drug resistance
E coli
Escherichia coli
Fungicides
Herbal medicine
increased activity
Levofloxacin
Nosocomial infection
Nosocomial infections
Protocatechuic acid
Pseudomonas aeruginosa
Staphylococcus aureus
Variance analysis
Yeasts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3
cites cdi_FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3
container_end_page
container_issue 7
container_start_page 1010
container_title Life (Basel, Switzerland)
container_volume 12
creator Fifere, Adrian
Turin-Moleavin, Ioana-Andreea
Rosca, Irina
description The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.
doi_str_mv 10.3390/life12071010
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_4d7c5e37dbaa4c7c9ae78dd6ac91258c</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_4d7c5e37dbaa4c7c9ae78dd6ac91258c</doaj_id><sourcerecordid>2695289707</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3</originalsourceid><addsrcrecordid>eNpdkjtvFDEQgC0EIlFIxw9YiYaCC-P1uwGdLgQiRYKCNDSW1487n3bXwfZGun-Pw0Uowc3M2J8-j-xB6C2GC0IUfBxj8LgHgQHDC3TaMrbColcvn-Qn6LyUPbTFGeaSvkYnhEkpQclT9Osy-dL9yKkma6q3uyXabm2j69YheFu7uvOtrvE-1kOXQrdJ05Tm8dDdFt-gucYhphpt6cx8rMMyb81YPr9Br0KL_vwxnqHbqy8_N99WN9-_Xm_WNytLGasrBcw5RcNgjORAgnGCKMbAAbeB9tYwYQfggQLlnglpelCglBSYGxzYQM7Q9dHrktnruxwnkw86maj_bqS81Sa3DkevqROWeSJcu4xaYZXxQjrHjVW4Z9I216ej624ZJu-sn2s24zPp85M57vQ23WtFMAfMm-D9oyCn34svVU-xWD-OZvZpKbrnivVSCRANffcfuk9LnttTPVAU2q9y2agPR8rmVEr24V8zGPTDDOinM0D-AOFjovw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2694007168</pqid></control><display><type>article</type><title>Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?</title><source>ProQuest - Publicly Available Content Database</source><source>PubMed Central</source><creator>Fifere, Adrian ; Turin-Moleavin, Ioana-Andreea ; Rosca, Irina</creator><creatorcontrib>Fifere, Adrian ; Turin-Moleavin, Ioana-Andreea ; Rosca, Irina</creatorcontrib><description>The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.</description><identifier>ISSN: 2075-1729</identifier><identifier>EISSN: 2075-1729</identifier><identifier>DOI: 10.3390/life12071010</identifier><identifier>PMID: 35888098</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antibacterial activity ; Antibiotics ; antifungals ; Bacterial infections ; Chemotherapy ; Communication ; Disks ; Drug development ; Drug resistance ; E coli ; Escherichia coli ; Fungicides ; Herbal medicine ; increased activity ; Levofloxacin ; Nosocomial infection ; Nosocomial infections ; Protocatechuic acid ; Pseudomonas aeruginosa ; Staphylococcus aureus ; Variance analysis ; Yeasts</subject><ispartof>Life (Basel, Switzerland), 2022-07, Vol.12 (7), p.1010</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3</citedby><cites>FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3</cites><orcidid>0000-0003-3080-1709</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2694007168/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2694007168?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><creatorcontrib>Fifere, Adrian</creatorcontrib><creatorcontrib>Turin-Moleavin, Ioana-Andreea</creatorcontrib><creatorcontrib>Rosca, Irina</creatorcontrib><title>Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?</title><title>Life (Basel, Switzerland)</title><description>The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.</description><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>antifungals</subject><subject>Bacterial infections</subject><subject>Chemotherapy</subject><subject>Communication</subject><subject>Disks</subject><subject>Drug development</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Fungicides</subject><subject>Herbal medicine</subject><subject>increased activity</subject><subject>Levofloxacin</subject><subject>Nosocomial infection</subject><subject>Nosocomial infections</subject><subject>Protocatechuic acid</subject><subject>Pseudomonas aeruginosa</subject><subject>Staphylococcus aureus</subject><subject>Variance analysis</subject><subject>Yeasts</subject><issn>2075-1729</issn><issn>2075-1729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkjtvFDEQgC0EIlFIxw9YiYaCC-P1uwGdLgQiRYKCNDSW1487n3bXwfZGun-Pw0Uowc3M2J8-j-xB6C2GC0IUfBxj8LgHgQHDC3TaMrbColcvn-Qn6LyUPbTFGeaSvkYnhEkpQclT9Osy-dL9yKkma6q3uyXabm2j69YheFu7uvOtrvE-1kOXQrdJ05Tm8dDdFt-gucYhphpt6cx8rMMyb81YPr9Br0KL_vwxnqHbqy8_N99WN9-_Xm_WNytLGasrBcw5RcNgjORAgnGCKMbAAbeB9tYwYQfggQLlnglpelCglBSYGxzYQM7Q9dHrktnruxwnkw86maj_bqS81Sa3DkevqROWeSJcu4xaYZXxQjrHjVW4Z9I216ej624ZJu-sn2s24zPp85M57vQ23WtFMAfMm-D9oyCn34svVU-xWD-OZvZpKbrnivVSCRANffcfuk9LnttTPVAU2q9y2agPR8rmVEr24V8zGPTDDOinM0D-AOFjovw</recordid><startdate>20220707</startdate><enddate>20220707</enddate><creator>Fifere, Adrian</creator><creator>Turin-Moleavin, Ioana-Andreea</creator><creator>Rosca, Irina</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3080-1709</orcidid></search><sort><creationdate>20220707</creationdate><title>Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?</title><author>Fifere, Adrian ; Turin-Moleavin, Ioana-Andreea ; Rosca, Irina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>antifungals</topic><topic>Bacterial infections</topic><topic>Chemotherapy</topic><topic>Communication</topic><topic>Disks</topic><topic>Drug development</topic><topic>Drug resistance</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Fungicides</topic><topic>Herbal medicine</topic><topic>increased activity</topic><topic>Levofloxacin</topic><topic>Nosocomial infection</topic><topic>Nosocomial infections</topic><topic>Protocatechuic acid</topic><topic>Pseudomonas aeruginosa</topic><topic>Staphylococcus aureus</topic><topic>Variance analysis</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fifere, Adrian</creatorcontrib><creatorcontrib>Turin-Moleavin, Ioana-Andreea</creatorcontrib><creatorcontrib>Rosca, Irina</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Life (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fifere, Adrian</au><au>Turin-Moleavin, Ioana-Andreea</au><au>Rosca, Irina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?</atitle><jtitle>Life (Basel, Switzerland)</jtitle><date>2022-07-07</date><risdate>2022</risdate><volume>12</volume><issue>7</issue><spage>1010</spage><pages>1010-</pages><issn>2075-1729</issn><eissn>2075-1729</eissn><abstract>The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>35888098</pmid><doi>10.3390/life12071010</doi><orcidid>https://orcid.org/0000-0003-3080-1709</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2075-1729
ispartof Life (Basel, Switzerland), 2022-07, Vol.12 (7), p.1010
issn 2075-1729
2075-1729
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_4d7c5e37dbaa4c7c9ae78dd6ac91258c
source ProQuest - Publicly Available Content Database; PubMed Central
subjects Antibacterial activity
Antibiotics
antifungals
Bacterial infections
Chemotherapy
Communication
Disks
Drug development
Drug resistance
E coli
Escherichia coli
Fungicides
Herbal medicine
increased activity
Levofloxacin
Nosocomial infection
Nosocomial infections
Protocatechuic acid
Pseudomonas aeruginosa
Staphylococcus aureus
Variance analysis
Yeasts
title Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T07%3A44%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20Protocatechuic%20Acid%20Affect%20the%20Activity%20of%20Commonly%20Used%20Antibiotics%20and%20Antifungals?&rft.jtitle=Life%20(Basel,%20Switzerland)&rft.au=Fifere,%20Adrian&rft.date=2022-07-07&rft.volume=12&rft.issue=7&rft.spage=1010&rft.pages=1010-&rft.issn=2075-1729&rft.eissn=2075-1729&rft_id=info:doi/10.3390/life12071010&rft_dat=%3Cproquest_doaj_%3E2695289707%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c455t-905dd94fbaa8603fad739550d06cf42ca57cb06f4046e578a2090998716a1f5b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2694007168&rft_id=info:pmid/35888098&rfr_iscdi=true