Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging

Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.12887-12887, Article 12887
Main Authors: Hu, Qing, Jiang, Peipei, Feng, Yongjing, Xu, Yan, Zhou, Nan, Chen, Weibo, Zhu, Li, Hu, Yali, Zhou, Zhengyang
Format: Article
Language:English
Subjects:
692/53/2421
692/699/2732
692/700/139
692/700/1421
Biomarkers
Cysts
Diffusion coefficient
Endometrium
Extracellular matrix
Fibrosis
Hospitals
Humanities and Social Sciences
Magnetic resonance imaging
multidisciplinary
Patients
Regression analysis
Reproducibility
Science
Science (multidisciplinary)
Uterus
Women
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Summary:Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient ( D ), pseudodiffusion coefficient ( D* ) and vascular fraction ( f ) were evaluated. A multivariable model combing ADC, D , and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D , f values and ET (all p  0.05). The reproducibility of ADC, D , f and D* values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92383-w