Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-05, Vol.29 (11), p.2503
• Main Authors: Bernasinska-Slomczewska, Joanna, Hikisz, Pawel, Pieniazek, Anna, Koceva-Chyla, Aneta
• Format: Article
• Language: English
• Subjects: Analysis; Angiogenesis; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; baicalein; baicalin; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cancer cells; Cancer therapies; Cardiovascular disease; Cell cycle; Cell Survival - drug effects; Chemotherapy; Cytotoxicity; DNA damage; DNA Damage - drug effects; Docetaxel; Docetaxel - pharmacology; doxorubicin; Doxorubicin - pharmacology; Drug dosages; Drug resistance; Drug Synergism; Endothelium; Female; Flavanones - pharmacology; Flavonoids; Flavonoids - pharmacology; Herbal medicine; Human Umbilical Vein Endothelial Cells - drug effects; Humans; Inflammation; Isoflavones; MCF-7 Cells; Metastasis; Mortality; Patients; Toxicity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29112503

Breast cancer is a major health concern and the leading cause of death among women worldwide. Standard treatment often involves surgery, radiotherapy, and chemotherapy, but these come with side effects and limitations. Researchers are exploring natural compounds like baicalin and baicalein, derived from the plant, as potential complementary therapies. This study investigated the effects of baicalin and baicalein on the cytotoxic, proapoptotic, and genotoxic activity of doxorubicin and docetaxel, commonly used chemotherapeutic drugs for breast cancer. The analysis included breast cancer cells (MCF-7) and human endothelial cells (HUVEC-ST), to assess potential effects on healthy tissues. We have found that baicalin and baicalein demonstrated cytotoxicity towards both cell lines, with more potent effects observed in baicalein. Both flavonoids, baicalin (167 µmol/L) and baicalein (95 µmol/L), synergistically enhanced the cytotoxic, proapoptotic, and genotoxic activity of doxorubicin and docetaxel in breast cancer cells. In comparison, their effects on endothelial cells were mixed and depended on concentration and time. The results suggest that baicalin and baicalein might be promising complementary agents to improve the efficacy of doxorubicin and docetaxel anticancer activity. However, further research is needed to validate their safety and efficacy in clinical trials.