Angiotensin I-Converting Enzyme Inhibitory Peptides of Chia (Salvia hispanica) Produced by Enzymatic Hydrolysis

Synthetic angiotensin I-converting enzyme (ACE-I) inhibitors can have undesirable side effects, while natural inhibitors have no side effects and are potential nutraceuticals. A protein-rich fraction from chia (Salvia hispanica L.) seed was hydrolyzed with an Alcalase-Flavourzyme sequential system a...

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Bibliographic Details
Published in:International journal of food science 2013, Vol.2013 (2013), p.1-8
Main Authors: Segura Campos, Maira Rubi, Peralta González, Fanny, Chel Guerrero, Luis, Betancur Ancona, David
Format: Article
Language:English
Subjects:
Bioavailability
Enzymes
Food
Hypertension
Laboratories
Molecular weight
Peptides
Pharmaceuticals
Proteins
Seeds
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Summary:Synthetic angiotensin I-converting enzyme (ACE-I) inhibitors can have undesirable side effects, while natural inhibitors have no side effects and are potential nutraceuticals. A protein-rich fraction from chia (Salvia hispanica L.) seed was hydrolyzed with an Alcalase-Flavourzyme sequential system and the hydrolysate ultrafiltered through four molecular weight cut-off membranes (1 kDa, 3 kDa, 5 kDa, and 10 kDa). ACE-I inhibitory activity was quantified in the hydrolysate and ultrafiltered fractions. The hydrolysate was extensive (DH = 51.64%) and had 58.46% ACE-inhibitory activity. Inhibition ranged from 53.84% to 69.31% in the five ultrafiltered fractions and was highest in the
ISSN:2356-7015
2314-5765
2314-5765
DOI:10.1155/2013/158482