The Effects of Acid on Calcium and Phosphate Metabolism

A variety of changes in mineral metabolism aiming to restore acid-base balance occur in acid loading and metabolic acidosis. Phosphate plays a key role in defense against metabolic acidosis, both as an intracellular and extracellular buffer, as well as in the renal excretion of excess acid in the fo...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (4), p.2081
Main Authors: Salcedo-Betancourt, Juan D, Moe, Orson W
Format: Article
Language:English
Subjects:
Acidosis
Acidosis - metabolism
calcium
Calcium - metabolism
Calcium, Dietary
Carbon dioxide
Carbonates
Citrates
Citric Acid
Creatinine
Decomposition
Drainage
Homeostasis
Humans
Hydroxyapatite
Hypokalemia
Kidney - metabolism
Kidney Diseases
Kidneys
Metabolism
Ostomy
phosphate
Phosphates
Phosphates - metabolism
Phosphorus
Physiological aspects
Proteins
Small intestine
Sodium
Urine
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Summary:A variety of changes in mineral metabolism aiming to restore acid-base balance occur in acid loading and metabolic acidosis. Phosphate plays a key role in defense against metabolic acidosis, both as an intracellular and extracellular buffer, as well as in the renal excretion of excess acid in the form of urinary titratable acid. The skeleton acts as an extracellular buffer in states of metabolic acidosis, as the bone matrix demineralizes, leading to bone apatite dissolution and the release of phosphate, calcium, carbonate, and citrate into the circulation. The renal handling of calcium, phosphate and citrate is also affected, with resultant hypercalciuria, hyperphosphaturia and hypocitraturia.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25042081