Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey

Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C....

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Bibliographic Details
Published in:The Turkish journal of gastroenterology 2022-10, Vol.33 (10), p.862-873
Main Authors: Onlen, Yusuf, Bal, Tayibe, Cabalak, Mehmet, Oztoprak, Nefise Cuvalci, Sari, Nagehan Didem, Kurtaran, Behice, Senates, Ebubekir, Gunduz, Alper, Zerdali, Esra, Karsen, Hasan, Batirel, Ayse, Karaali, Ridvan, Guner, Rahmet, Yamazhan, Tansu, Kose, Sukran, Erben, Nurettin, Ince, Nevin, Koksal, Iftihar, Yildirim, Figen Sarigul, Yoruk, Gulden, Komur, Suheyla, Kaya, Sibel, Esen, Saban, Gunal, Ozgur, Yildiz, Ilknur Esen, Inan, Dilara, Barut, Sener, Namiduru, Mustafa, Tosun, Selma, Turker, Kamuran, Sener, Alper, Hizel, Kenan, Baykam, Nurcan, Duygu, Fazilet, Akinci, Esragul, Can, Guray, User, Ulku, Gul, Hanefi Cem, Akbulut, Ayhan, Celebi, Guven, Sunnetcioglu, Mahmut, Karabay, Oguz, Karaosmanoglu, Hayat Kumbasar, Sirmatel, Fatma, Tabak, Fehmi
Format: Article
Language:English
Subjects:
Aged patients
Antiviral agents
Dosage and administration
Drug therapy
Hepatitis C
Patient outcomes
Pharmacology, Experimental
Physiological aspects
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Summary:Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly ([greater than or equal to]65 years) and younger adults (
ISSN:1300-4948
2148-5607
DOI:10.5152/tjg.2022.21271