Triggering Immune System With Nanomaterials for Cancer Immunotherapy

Cancer is a major cause of incidence rate and mortality worldwide. In recent years, cancer immunotherapy has made great progress in the preclinical and clinical treatment of advanced malignant tumors. However, cancer patients will have transient cancer suppression reaction and serious immune related...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-04, Vol.10, p.878524
Main Authors: Li, Qiyan, Liu, Yulin, Huang, Zihua, Guo, Yajie, Li, Qingjiao
Format: Article
Language:English
Subjects:
Bioengineering and Biotechnology
cancer immunotherapy
delivery system
nanomaterials
nanovaccines
photodynamic immunotherapy
photothermal immunotherapy
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Summary:Cancer is a major cause of incidence rate and mortality worldwide. In recent years, cancer immunotherapy has made great progress in the preclinical and clinical treatment of advanced malignant tumors. However, cancer patients will have transient cancer suppression reaction and serious immune related adverse reactions when receiving immunotherapy. In recent years, nanoparticle-based immunotherapy, which can accurately deliver immunogens, activate antigen presenting cells (APCs) and effector cells, provides a new insight to solve the above problems. In this review, we discuss the research progress of nanomaterials in immunotherapy including nanoparticle-based delivery systems, nanoparticle-based photothermal and photodynamic immunotherapy, nanovaccines, nanoparticle-based T cell cancer immunotherapy and nanoparticle-based bacteria cancer immunotherapy. We also put forward the current challenges and prospects of immunomodulatory therapy.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.878524