Mapping cancer biology in space: applications and perspectives on spatial omics for oncology

Technologies to decipher cellular biology, such as bulk sequencing technologies and single-cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent findings in tumor biology suggest that tumors construct architectures that influence the underlying cancerous mechani...

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Bibliographic Details
Published in:Molecular cancer 2024-01, Vol.23 (1), p.26-27, Article 26
Main Authors: Lee, Sumin, Kim, Gyeongjun, Lee, JinYoung, Lee, Amos C, Kwon, Sunghoon
Format: Article
Language:English
Subjects:
Biology
Biomarkers
Cancer
Cancer research
Cells
Gene expression
Genomes
Humans
Lasers
Medical Oncology
Medical research
Metastasis
Morphology
Mutation
Neoplasms - genetics
Oncology
Proteins
Review
Spacecraft
Spatial analysis
Technology
Tumor microenvironment
Tumor Microenvironment - genetics
Tumors
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Summary:Technologies to decipher cellular biology, such as bulk sequencing technologies and single-cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent findings in tumor biology suggest that tumors construct architectures that influence the underlying cancerous mechanisms. Increasing research has reported novel techniques to map the tissue in a spatial context or targeted sampling-based characterization and has introduced such technologies to solve oncology regarding tumor heterogeneity, tumor microenvironment, and spatially located biomarkers. In this study, we address spatial technologies that can delineate the omics profile in a spatial context, novel findings discovered via spatial technologies in oncology, and suggest perspectives regarding therapeutic approaches and further technological developments.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-024-01941-z