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Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy
Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies. Purpose: To revie...
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| Published in: | Cancer control 2022-12, Vol.29, p.10732748221144458 |
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| creator | Weppelmann, Thomas A. Khalil, Sabrina Zafrullah, Nabeel Amir, Sabah Margo, Curtis E. |
| description | Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies.
Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years.
Study Design: Literature review with structured data abstraction.
Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult.
Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials. |
| doi_str_mv | 10.1177/10732748221144458 |
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Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years.
Study Design: Literature review with structured data abstraction.
Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult.
Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials.</description><identifier>ISSN: 1073-2748</identifier><identifier>ISSN: 1526-2359</identifier><identifier>EISSN: 1526-2359</identifier><identifier>DOI: 10.1177/10732748221144458</identifier><identifier>PMID: 36473045</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Autoimmune Diseases ; Bullous pemphigoid ; Cancer ; Cell Proliferation ; Clinical trials ; Commissioned work; full APC waiver ; Encephalopathy ; Eye diseases ; Humans ; Literature reviews ; Occipital lobe ; Paraneoplastic Syndromes, Ocular - diagnosis ; Paraneoplastic Syndromes, Ocular - therapy ; Plasmapheresis ; Retinal Diseases ; Retinopathy ; Tumors ; Visual system</subject><ispartof>Cancer control, 2022-12, Vol.29, p.10732748221144458</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022 2022 SAGE Publications Inc, unless otherwise noted. Manuscript content on this site is licensed under Creative Common Licences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-b724ea4097978d8dc339740243dd6272537d0672ad79e42a46cbfca555f5189c3</citedby><cites>FETCH-LOGICAL-c532t-b724ea4097978d8dc339740243dd6272537d0672ad79e42a46cbfca555f5189c3</cites><orcidid>0000-0003-1852-5369</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732803/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2758347431?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,21966,25753,27853,27924,27925,37012,37013,44590,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36473045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weppelmann, Thomas A.</creatorcontrib><creatorcontrib>Khalil, Sabrina</creatorcontrib><creatorcontrib>Zafrullah, Nabeel</creatorcontrib><creatorcontrib>Amir, Sabah</creatorcontrib><creatorcontrib>Margo, Curtis E.</creatorcontrib><title>Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy</title><title>Cancer control</title><addtitle>Cancer Control</addtitle><description>Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies.
Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years.
Study Design: Literature review with structured data abstraction.
Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult.
Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials.</description><subject>Autoimmune Diseases</subject><subject>Bullous pemphigoid</subject><subject>Cancer</subject><subject>Cell Proliferation</subject><subject>Clinical trials</subject><subject>Commissioned work; full APC waiver</subject><subject>Encephalopathy</subject><subject>Eye diseases</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Occipital lobe</subject><subject>Paraneoplastic Syndromes, Ocular - diagnosis</subject><subject>Paraneoplastic Syndromes, Ocular - therapy</subject><subject>Plasmapheresis</subject><subject>Retinal Diseases</subject><subject>Retinopathy</subject><subject>Tumors</subject><subject>Visual system</subject><issn>1073-2748</issn><issn>1526-2359</issn><issn>1526-2359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kktv1DAQgCMEoqXwA7ggS1y4pPgZJxyQVsurUlEroGdrYjtbrxx7sZOF_fd42VIoiJOtmW8-j-2pqqcEnxIi5UuCJaOSt5QSwjkX7b3qmAja1JSJ7n7Zl3y9B46qRzmvMaaYM_6wOmINlwxzcVx9v9Czh4QuIUGwceMhT06jz7tgUhxtfoUWaJlciYFHn-zW2W8oDuiNG4Y5W3S1tSX-0XoIUe_2lZcpejfYBJOLAUEwaDFP0Y3jHGwRTC7EDUzXu8fVgwF8tk9u1pPq6t3bL8sP9fnF-7Pl4rzWgtGp7iXlFjjuZCdb0xrNWCc5ppwZ01BJBZMGN5KCkZ3lFHij-0GDEGIQpO00O6nODl4TYa02yY2QdiqCUz8DMa0UpNK4t4ob3TdMsp5hwxveAzZMCCJ7a1pBRF9crw-uzdyP1mgbpgT-jvRuJrhrtYpb1ZV_ajErghc3ghS_zjZPanRZW-_3bz9nRWW5dIcZpQV9_he6jnMK5an2VMu45IwUihwonWLOyQ63zRCs9jOi_pmRUvPsz1vcVvwaigKcHoAMK_v72P8bfwCSu8Sm</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Weppelmann, Thomas A.</creator><creator>Khalil, Sabrina</creator><creator>Zafrullah, Nabeel</creator><creator>Amir, Sabah</creator><creator>Margo, Curtis E.</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><general>SAGE Publishing</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1852-5369</orcidid></search><sort><creationdate>20221201</creationdate><title>Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy</title><author>Weppelmann, Thomas A. ; Khalil, Sabrina ; Zafrullah, Nabeel ; Amir, Sabah ; Margo, Curtis E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-b724ea4097978d8dc339740243dd6272537d0672ad79e42a46cbfca555f5189c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Autoimmune Diseases</topic><topic>Bullous pemphigoid</topic><topic>Cancer</topic><topic>Cell Proliferation</topic><topic>Clinical trials</topic><topic>Commissioned work; full APC waiver</topic><topic>Encephalopathy</topic><topic>Eye diseases</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Occipital lobe</topic><topic>Paraneoplastic Syndromes, Ocular - diagnosis</topic><topic>Paraneoplastic Syndromes, Ocular - therapy</topic><topic>Plasmapheresis</topic><topic>Retinal Diseases</topic><topic>Retinopathy</topic><topic>Tumors</topic><topic>Visual system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weppelmann, Thomas A.</creatorcontrib><creatorcontrib>Khalil, Sabrina</creatorcontrib><creatorcontrib>Zafrullah, Nabeel</creatorcontrib><creatorcontrib>Amir, Sabah</creatorcontrib><creatorcontrib>Margo, Curtis E.</creatorcontrib><collection>SAGE Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cancer control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weppelmann, Thomas A.</au><au>Khalil, Sabrina</au><au>Zafrullah, Nabeel</au><au>Amir, Sabah</au><au>Margo, Curtis E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy</atitle><jtitle>Cancer control</jtitle><addtitle>Cancer Control</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>29</volume><spage>10732748221144458</spage><pages>10732748221144458-</pages><issn>1073-2748</issn><issn>1526-2359</issn><eissn>1526-2359</eissn><abstract>Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies.
Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years.
Study Design: Literature review with structured data abstraction.
Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult.
Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>36473045</pmid><doi>10.1177/10732748221144458</doi><orcidid>https://orcid.org/0000-0003-1852-5369</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Autoimmune Diseases Bullous pemphigoid Cancer Cell Proliferation Clinical trials Commissioned work full APC waiver Encephalopathy Eye diseases Humans Literature reviews Occipital lobe Paraneoplastic Syndromes, Ocular - diagnosis Paraneoplastic Syndromes, Ocular - therapy Plasmapheresis Retinal Diseases Retinopathy Tumors Visual system |
| title | Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy |
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