The Kinetics of Chitosan Degradation in Organic Acid Solutions

This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics. More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (p...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2021-04, Vol.19 (5), p.236
Main Authors: Sikorski, Dominik, Gzyra-Jagieła, Karolina, Draczyński, Zbigniew
Format: Article
Language:English
Subjects:
Acetic acid
Acids
Analytical methods
Chitosan
Chromatography
Comparative analysis
Comparative studies
Constants
Cytokines
Degradation
Dissociation
dissociation constant
Drug delivery
Kinetics
Magnetic resonance spectroscopy
Nanocomposites
NMR
NMR spectroscopy
Nuclear magnetic resonance
Organic acids
Photodegradation
Polymers
Solvents
Viscosity
Viscosity measurement
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics. More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values). The scientists involved in chitosan to date have focused mainly on acetic acid solutions. Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt. were used in this research. The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation. Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days). The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis. The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing. Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19050236