Assembly and regulation of γ-tubulin complexes

Microtubules are major constituents of the cytoskeleton in all eukaryotic cells. They are essential for chromosome segregation during cell division, for directional intracellular transport and for building specialized cellular structures such as cilia or flagella. Their assembly has to be controlled...

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Bibliographic Details
Published in:Open biology 2018-03, Vol.8 (3)
Main Authors: Farache, Dorian, Emorine, Laurent, Haren, Laurence, Merdes, Andreas
Format: Article
Language:English
Subjects:
Cellular Biology
Centrosome
Cm1 Proteins
Gamma-Tubulin
Gamma-Tubulin Complex Proteins
Life Sciences
Microtubule Nucleation
Microtubule-Organizing Centres
Review
Subcellular Processes
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Summary:Microtubules are major constituents of the cytoskeleton in all eukaryotic cells. They are essential for chromosome segregation during cell division, for directional intracellular transport and for building specialized cellular structures such as cilia or flagella. Their assembly has to be controlled spatially and temporally. For this, the cell uses multiprotein complexes containing γ-tubulin. γ-Tubulin has been found in two different types of complexes, γ-tubulin small complexes and γ-tubulin ring complexes. Binding to adaptors and activator proteins transforms these complexes into structural templates that drive the nucleation of new microtubules in a highly controlled manner. This review discusses recent advances on the mechanisms of assembly, recruitment and activation of γ-tubulin complexes at microtubule-organizing centres.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.170266