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Aquaporin-5 Dynamic Regulation

Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water channels, facilitates osmotically driven water flux across biological membranes and the movement of hydrogen peroxide and CO . Various mechanisms have been shown to dynamically regulate AQP5 expression, trafficking,...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (3), p.1889
Main Authors: D'Agostino, Claudia, Parisis, Dorian, Chivasso, Clara, Hajiabbas, Maryam, Soyfoo, Muhammad Shahnawaz, Delporte, Christine
Format: Article
Language:English
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Summary:Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water channels, facilitates osmotically driven water flux across biological membranes and the movement of hydrogen peroxide and CO . Various mechanisms have been shown to dynamically regulate AQP5 expression, trafficking, and function. Besides fulfilling its primary water permeability function, AQP5 has been shown to regulate downstream effectors playing roles in various cellular processes. This review provides a comprehensive overview of the current knowledge of the upstream and downstream effectors of AQP5 to gain an in-depth understanding of the physiological and pathophysiological processes involving AQP5.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24031889