Wound Modulations in Glaucoma Surgery: A Systematic Review

Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpred...

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Bibliographic Details
Published in:Bioengineering (Basel) 2024-05, Vol.11 (5), p.446
Main Authors: Dave, Bhoomi, Patel, Monica, Suresh, Sruthi, Ginjupalli, Mahija, Surya, Arvind, Albdour, Mohannad, Kooner, Karanjit S
Format: Article
Language:English
Subjects:
5-Fluorouracil
Angiogenesis
anti-LOXL2 monoclonal Ab
anti-vascular endothelial growth factors
antifibrotic agents
Blood platelets
Blood vessels
Care and treatment
Chemokines
Corticosteroids
cytokine inhibitors
Diagnosis
Digital Object Identifier
Endothelium
Eye surgery
Fibroblasts
Fibrosis
Glaucoma
glaucoma surgery
Growth factors
Health aspects
Inflammation
Intraocular lenses
Intraocular pressure
Leukocytes
Mitomycin C
Neutrophils
Ostomy
Pathogens
Patient outcomes
Python
Surgery
Systematic review
Trabeculectomy
Wound healing
Wounds and injuries
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Summary:Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering11050446