Morphology and Biochemistry of Ovulation Morfologia e bioquímica da ovulação

Abstract The process of ovulation involves multiple and iterrelated genetic, biochemical, and morphological events: cessation of the proliferation of granulosa cells, resumption of oocyte meiosis, expansion of cumulus cell-oocyte complexes, digestion of the follicle wall, and extrusion of the metaph...

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Bibliographic Details
Published in:Revista Brasileira de ginecologia e obstetrícia 2021-09, Vol.43 (6), p.480-486
Main Authors: Medeiros, Sebastião Freitas de, Barbosa, Bruna Barcelo, Medeiros, Matheus Antonio Souto de, Yamamoto, Márcia Marly Winck
Format: Article
Language:eng ; por
Subjects:
follicle-stimulating hormone
granulosa cells
luteinizing hormone
OBSTETRICS & GYNECOLOGY
oocytes
ovarian follicle
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Summary:Abstract The process of ovulation involves multiple and iterrelated genetic, biochemical, and morphological events: cessation of the proliferation of granulosa cells, resumption of oocyte meiosis, expansion of cumulus cell-oocyte complexes, digestion of the follicle wall, and extrusion of the metaphase-II oocyte. The present narrative review examines these interrelated steps in detail. The combined or isolated roles of the folliclestimulating hormone (FSH) and luteinizing hormone (LH) are highlighted. Genes indiced by the FSH genes are relevant in the cumulus expansion, and LH-induced genes are critical for the resumption ofmeiosis and digestion of the follicle wall. A nonhuman model for follicle-wall digestion and oocyte release was provided.
ISSN:1806-9339
0100-7203
DOI:10.1055/s-0041-1731379