Plasmid DNA for Therapeutic Applications in Cancer

Recently, the interest in using nucleic acids for therapeutic applications has been increasing. DNA molecules can be manipulated to express a gene of interest for gene therapy applications or vaccine development. Plasmid DNA can be developed to treat different diseases, such as infections and cancer...

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Bibliographic Details
Published in:Pharmaceutics 2022-09, Vol.14 (9), p.1861
Main Authors: Martínez-Puente, David Hernán, Pérez-Trujillo, José Juan, Zavala-Flores, Laura Mireya, García-García, Aracely, Villanueva-Olivo, Arnulfo, Rodríguez-Rocha, Humberto, Valdés, Jesús, Saucedo-Cárdenas, Odila, Montes de Oca-Luna, Roberto, Loera-Arias, María de Jesús
Format: Article
Language:English
Subjects:
Antigens
apoptosis
Breast cancer
cancer
Cancer patients
Cancer therapies
Care and treatment
Cytomegalovirus
Cytotoxicity
DNA methylation
DNA vaccination
DNA vaccines
Dosage and administration
Enzymes
Gene expression
Gene therapy
Kinases
Lung cancer
Metastasis
Nanoparticles
Patient outcomes
Peptides
Plasmids
Prostate cancer
Proteins
Review
Telomerase
Transcription factors
tumor-specific antigens
Tumors
Vaccines
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Summary:Recently, the interest in using nucleic acids for therapeutic applications has been increasing. DNA molecules can be manipulated to express a gene of interest for gene therapy applications or vaccine development. Plasmid DNA can be developed to treat different diseases, such as infections and cancer. In most cancers, the immune system is limited or suppressed, allowing cancer cells to grow. DNA vaccination has demonstrated its capacity to stimulate the immune system to fight against cancer cells. Furthermore, plasmids for cancer gene therapy can direct the expression of proteins with different functions, such as enzymes, toxins, and cytotoxic or proapoptotic proteins, to directly kill cancer cells. The progress and promising results reported in animal models in recent years have led to interesting clinical results. These DNA strategies are expected to be approved for cancer treatment in the near future. This review discusses the main strategies, challenges, and future perspectives of using plasmid DNA for cancer treatment.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14091861