Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Path...

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Bibliographic Details
Published in:Frontiers in oncology 2014-01, Vol.4, p.160-160
Main Authors: Knight, Thomas, Irving, Julie Anne Elizabeth
Format: Article
Language:English
Subjects:
acute lymphoblastic leukaemia
Child
mek inhibitor
Oncology
Ras/Raf/MEK/Erk pathway
targeted therapy
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Summary:Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutically exploited and may guide new therapies needed for relapsed acute lymphoblastic leukemia and other high risk subgroups.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2014.00160