Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer

• Published in: Revista de Gastroenterología de México (English Edition) 2019-04, Vol.84 (2), p.158-164
• Main Authors: Carlosama-Rosero, Y.H., Bolaños-Bravo, H., Sierra-Tórres, C.H., Rosero, E.A.
• Format: Article
• Language: English
• Subjects: Gastritis; Genotipo; Genotype; Helicobacter pylori; Linfoma; Lymphoma; Mucosa-associated lymphoid tissue; Tejido linfoide asociado a mucosas
• ISSN: 2255-534X; 2255-534X
• DOI: 10.1016/j.rgmxen.2018.03.012

Follicular gastritis is associated with Helicobacter pylori infection, but little is known of its relation to bacterial genotypes. Our aim was to establish the relation between follicular gastritis and different H. pylori strains. An analytic case-control study was conducted that included 36 patients with follicular gastritis (cases) and 83 with nonatrophic gastritis (controls). The sociodemographic information was obtained through a questionnaire. Biopsies were evaluated according to the Sydney System and the Wotherspoon scoring system. Helicobacter pylori genotyping was performed using the polymerase chain reaction technique. The quantitative variables were presented as mean and standard deviation and the qualitative variables as proportions and absolute frequency. The effect of each variable on outcome (follicular gastritis) was evaluated through the odds ratio and its 95% confidence interval. Statistical significance was set at a p