Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty

To examine the association of preoperative opioids and/or benzodiazepines on postoperative outcomes in total knee and hip arthroplasty, we retrospectively compared postoperative outcomes in those prescribed preoperative opioids and/or benzodiazepines versus those who were not who underwent elective...

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Bibliographic Details
Published in:Scientific reports 2021-05, Vol.11 (1), p.10528-10528, Article 10528
Main Authors: Doan, Lisa V., Padjen, Kristoffer, Ok, Deborah, Gover, Adam, Rashid, Jawad, Osmani, Bijan, Avraham, Shirley, Wang, Jing, Kendale, Samir
Format: Article
Language:English
Subjects:
692/308/409
692/700/565
Arthroplasty (knee)
Benzodiazepines
Hip
Humanities and Social Sciences
Joint surgery
Length of stay
multidisciplinary
Narcotics
Opioids
Population studies
Postoperative period
Respiration
Respiratory failure
Science
Science (multidisciplinary)
Total hip arthroplasty
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Summary:To examine the association of preoperative opioids and/or benzodiazepines on postoperative outcomes in total knee and hip arthroplasty, we retrospectively compared postoperative outcomes in those prescribed preoperative opioids and/or benzodiazepines versus those who were not who underwent elective total knee and hip arthroplasty at a single urban academic institution. Multivariable logistic regression was performed for readmission rate, respiratory failure, infection, and adverse cardiac events. Multivariable zero-truncated negative binomial regression was used for length of stay. After exclusions, there were 4307 adult patients in the study population, 2009 of whom underwent total knee arthroplasty and 2298 of whom underwent total hip arthroplasty. After adjusting for potential confounders, preoperative benzodiazepine use was associated with increased odds of readmission (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90083-z