Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population

• Published in: BMC cardiovascular disorders 2021-11, Vol.21 (1), p.570-570, Article 570
• Main Authors: Liu, Ruoyi, Zhang, Qiao, Peng, Nianchun, Xu, Shujing, Zhang, Miao, Hu, Ying, Chen, Zhengyi, Tang, Kun, He, Xi, Li, Yi, Shi, Lixin
• Format: Article
• Language: English
• Subjects: Aged; Atherosclerosis; Biomarkers; Biomarkers - blood; Blood pressure; Body fat; Body mass index; Body weight; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; China - epidemiology; Cholesterol; Complications and side effects; Coronary vessels; Creatinine; Cross-Sectional Studies; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - epidemiology; Diagnosis; Dyslipidemia; Dyslipidemias - blood; Dyslipidemias - epidemiology; Exercise; Female; Fibronectins; Fibronectins - blood; Glucose; Health aspects; Heart Disease Risk Factors; Heart failure; High density lipoprotein; Humans; Hypertension; Hypertension - epidemiology; Insulin resistance; Irisin; Male; Measurement; Metabolic disorders; Metabolism; Middle Aged; Obesity; Obesity - blood; Obesity - diagnosis; Obesity - epidemiology; Overweight; Overweight persons; Physical fitness; Physiological aspects; Population; Questionnaires; Risk Assessment; Risk factors; Smoking; Smoking - adverse effects; Smoking - epidemiology; Vein & artery diseases
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-021-02380-0

Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population. A total of 98 overweight and 93 obese subjects without clinical treatments were enrolled in this study. Subjects were then divided into two groups, based on the serum irisin level: a low irisin group (1.10-13.44 ng/ml) and a high irisin group (13.49-29.9 ng/ml). The clustering of CVRFs, smoking, diabetes mellitus, dyslipidemia and hypertension, was classified as 0, 1, 2 and ≥ 3 CVRFs. The demographic and baseline clinical characteristics of all participants were collected and serum irisin was measured. The high serum irisin group had significantly higher high-density lipoprotein cholesterol but lower fasting plasma glucose than the low serum irisin group. Additionally, the high serum irisin group had a significantly lower prevalence of smoking, diabetes mellitus and dyslipidemia than the low serum irisin group. Increased serum irisin was significantly associated with a reduced risk of smoking and dyslipidemia in both the unadjusted and adjusted models. Furthermore, high serum irisin significantly reduced the risk of the prevalence of 1, 2 and ≥ 3 CVRFs. among the Chinese overweight/obese populations, high serum irisin is negatively associated with smoking, dyslipidemia and the clustering of CVRFs. Thus, high serum irisin is potentially associated with a low risk of cardiovascular diseases in the Chinese overweight/obese population.