A fertile male with a single sY86 deletion on the Y chromosome

Following the EAA/EMQN guidelines, we performed an extended analysis of the AZFa region by single-site PCR amplification to confirmation of the deletion and exclude false-positive results. [1] USP9Y has been reported to regulate sperm production,[9] and mutations in the DDX3Y gene could lead to male...

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Bibliographic Details
Published in:Asian journal of andrology 2020-05, Vol.22 (3), p.333-334
Main Authors: Jia, Yin, Niu, Zi-Guang, Li, Wei-Yu, Qin, Qin, Sun, Ting-Ting, Zhang, Feng, Liu, Shan-Rong
Format: Article
Language:English
Subjects:
Biopsy
Chromosomes
Deoxyribonucleic acid
DNA
Fertility
Genes
Genetic counseling
Infertility
Letter to the Editor
Males
Patients
Sperm
Spermatogenesis
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Summary:Following the EAA/EMQN guidelines, we performed an extended analysis of the AZFa region by single-site PCR amplification to confirmation of the deletion and exclude false-positive results. [1] USP9Y has been reported to regulate sperm production,[9] and mutations in the DDX3Y gene could lead to male infertility and a decrease in the number of germ cells. Even if YCM testing is widely used in the diagnosis and screening of patients with reproductive disorders, additional genetic testing should be conducted to verify and ensure the accuracy of data when various severe microdeletions involving the AZF region are observed.
ISSN:1008-682X
1745-7262
DOI:10.4103/aja.aja_94_19