Compensatory mechanisms of reduced interhemispheric EEG connectivity during sleep in patients with apnea

We performed a mathematical analysis of functional connectivity in electroencephalography (EEG) of patients with obstructive sleep apnea (OSA) (N = 10; age: 52.8 ± 13 years; median age: 49 years; male/female ratio: 7/3), compared with a group of apparently healthy participants (N = 15; age: 51.5 ± 2...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.8444-8444, Article 8444
Main Authors: Zhuravlev, Maksim, Agaltsov, Mikhail, Kiselev, Anton, Simonyan, Margarita, Novikov, Mikhail, Selskii, Anton, Ukolov, Rodion, Drapkina, Oksana, Orlova, Anna, Penzel, Thomas, Runnova, Anastasiya
Format: Article
Language:English
Subjects:
631/1647/1453/1450
631/57/2266
639/705/1041
639/766/530/2803
692/617/375/1816
Adult
Age
Aged
Aged, 80 and over
Apnea
Cerebral hemispheres
EEG
Electroencephalography
Electroencephalography - methods
Female
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Neural networks
REM sleep
Science
Science (multidisciplinary)
Sleep
Sleep and wakefulness
Sleep apnea
Sleep Apnea, Obstructive
Sleep disorders
Sleep Stages
Sleep, REM
Synchronization
Wakefulness
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We performed a mathematical analysis of functional connectivity in electroencephalography (EEG) of patients with obstructive sleep apnea (OSA) (N = 10; age: 52.8 ± 13 years; median age: 49 years; male/female ratio: 7/3), compared with a group of apparently healthy participants (N = 15; age: 51.5 ± 29.5 years; median age: 42 years; male/female ratio: 8/7), based on the calculation of wavelet bicoherence from nighttime polysomnograms. Having observed the previously known phenomenon of interhemispheric synchronization deterioration, we demonstrated a compensatory increase in intrahemispheric connectivity, as well as a slight increase in the connectivity of the central and occipital areas for high-frequency EEG activity. Significant changes in functional connectivity were extremely stable in groups of apparently healthy participants and OSA patients, maintaining the overall pattern when comparing different recording nights and various sleep stages. The maximum variability of the connectivity was observed at fast oscillatory processes during REM sleep. The possibility of observing some changes in functional connectivity of brain activity in OSA patients in a state of passive wakefulness opens up prospects for further research. Developing the methods of hypnogram evaluation that are independent of functional connectivity may be useful for implementing a medical decision support system.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-35376-1