Diagnostic ability and sectoral structure–function relationship of circumpapillary and macular superficial vessel density in early glaucomatous eyes

This study aimed to evaluate the diagnostic ability and sectoral structure function relationship of circumpapillary vessel density (cpVD) and macular vessel density (mVD) with optical coherence tomography angiography (OCTA) in early glaucomatous (EG) eyes. 224 EG eyes of 167 patients (mean deviation...

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Published in:Scientific reports 2022-04, Vol.12 (1), p.5991-5991, Article 5991
Main Authors: Akiyama, Kaho, Saito, Hitomi, Shirato, Shiroaki, Iwase, Aiko, Sugimoto, Koichiro, Fujishiro, Takashi, Murata, Hiroshi, Sakata, Rei, Honjo, Megumi, Aihara, Makoto
Format: Article
Language:English
Subjects:
692/699/3161/3169/3170
692/699/3161/3172
Angiography
Cross-Sectional Studies
Eye
Glaucoma
Glaucoma, Open-Angle
Humanities and Social Sciences
Humans
Intraocular Pressure
Medical imaging
multidisciplinary
Nerve Fibers
Optic Disk - diagnostic imaging
Optics
Retinal Ganglion Cells
Retinal Vessels - diagnostic imaging
Retrospective Studies
Science
Science (multidisciplinary)
Structure-Activity Relationship
Structure-function relationships
Tomography
Tomography, Optical Coherence - methods
Trends
Visual field
Visual Field Tests
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Summary:This study aimed to evaluate the diagnostic ability and sectoral structure function relationship of circumpapillary vessel density (cpVD) and macular vessel density (mVD) with optical coherence tomography angiography (OCTA) in early glaucomatous (EG) eyes. 224 EG eyes of 167 patients (mean deviation (MD) > − 6 dB) and 70 normal eyes of 70 subjects were enrolled in this retrospective cross-sectional study. All patients underwent OCT and OCTA scanning. Diagnostic abilities were evaluated with area under receiver operating characteristic curves (AUROC). Structure function relationships of superior, inferior and Garway-Heath sectoral values with its corresponding visual field (VF) sensitivity were determined using linear mixed models. AUROCs were 0.798, 0.621, 0.876 and 0.835 for cpVD, mVD, circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and ganglion cell-inner plexiform layer, respectively. AUROC of cpVD was significantly lower than cpRNFLT ( P  = 0.010) and higher than mVD ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10033-1