The epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents

Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Yet, it remains elusive if such biomarkers are associated with aging-related outcomes earlier...

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Bibliographic Details
Published in:Clinical epigenetics 2018-07, Vol.10 (1), p.96-96, Article 96
Main Authors: Suarez, Anna, Lahti, Jari, Czamara, Darina, Lahti-Pulkkinen, Marius, Girchenko, Polina, Andersson, Sture, Strandberg, Timo E, Reynolds, Rebecca M, Kajantie, Eero, Binder, Elisabeth B, Raikkonen, Katri
Format: Article
Language:English
Subjects:
Adolescent
Adolescent Behavior
Adolescent Development
Adolescents
Aging
Aging (Biology)
Aging - genetics
Aging - metabolism
Aging - psychology
Analysis
Behavior disorders
Biomarkers
Body height
Body Mass Index
Child
Child & adolescent psychiatry
Child Behavior
Child Development
Children & youth
Cognition
Cognition & reasoning
Cognitive ability
Cortisol
Deoxyribonucleic acid
Developmental stages
DNA
DNA Methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Female
Geriatrics
Health aspects
Health risk assessment
Hormones
Humans
Hydrocortisone - analysis
Male
Middle age
Morbidity
Mortality
Physiology
Pregnancy
Psychological aspects
Puberty - genetics
Risk factors
Studies
Teenagers
Youth
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Summary:Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Yet, it remains elusive if such biomarkers are associated with aging-related outcomes earlier in life when individuals begin to diverge in aging trajectories. We tested if the Horvath epigenetic age predictor is associated with pubertal, neuroendocrine, psychiatric, and cognitive aging-related outcomes in a sample of 239 adolescents, 11.0-13.2 years-old. Each year increase in epigenetic age acceleration (AA) was associated with 0.06 SD units higher weight-for-age, 0.08 SD units taller height-for-age, -0.09 SD units less missed from the expected adult height, 13 and 16% higher odds, respectively, for each stage increase in breast/genitals development on the Tanner Staging Questionnaire and pubertal stage on the Pubertal Development Scale, 4.2% higher salivary cortisol upon awakening, and 18 to 34% higher odds for internalizing and thought problems on the Child Behavior Checklist (p values 
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-018-0528-6