Microbial Distribution and Antibiotic Susceptibility of Bloodstream Infections in Different Intensive Care Units

Bloodstream infection (BSI) is an increasing public health concern worldwide, representing a serious infection with significant morbidity and mortality, especially in children and the elderly. The predominant microbial distribution and antibiotic susceptibility were investigated among BSIs in the di...

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Bibliographic Details
Published in:Frontiers in microbiology 2021-12, Vol.12, p.792282-792282
Main Authors: Duan, Nan, Sun, Liying, Huang, Chenwei, Li, Haixia, Cheng, Bin
Format: Article
Language:English
Subjects:
antibiotic susceptibility
bloodstream infections
Klebsiella pneumoniae
microbial distributions
Microbiology
Staphylococcus hominis
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Summary:Bloodstream infection (BSI) is an increasing public health concern worldwide, representing a serious infection with significant morbidity and mortality, especially in children and the elderly. The predominant microbial distribution and antibiotic susceptibility were investigated among BSIs in the different intensive care units (ICUs)-pediatric ICU (PICU), surgical ICU (SICU), cardiac ICU (CICU), respiratory ICU (RICU), and geriatric ICU (GICU)-in order to achieve more efficient and appropriate therapies for patients in various ICUs. In this retrospective cross-sectional study, the blood specimens were collected from five different ICUs of Peking University First Hospital and comprehensive ICU of Miyun Teaching Hospital (Miyun ICU) before antimicrobial treatment from 2017 to 2020. Microorganism cultures of the blood samples were conducted, and positive cultures were tested for type of pathogens and drug susceptibility. The prevalence of BSIs was the highest in the Miyun ICU (10.85%), followed by the RICU (9.48%) and the PICU (8.36%). The total prevalence of Gram-positive bacterial strains (especially and ) in the PICU (44.55%), SICU (57.58%), CICU (55.00%), GICU (49.06%), and Miyun ICU (57.58%) was higher than that of Gram-negative bacteria. The major bacterial strain was in the PICU (21.82%); in the SICU (12.88%), CICU (30.00%), and RICU (30.39%); in the GICU (20.75%); and (18.18%) in the Miyun ICU. of BSIs remained highly susceptible (>70%) to gentamicin, linezolid, daptomycin, teicoplanin, vancomycin, tigecycline, and rifampicin in all the ICUs. Its antibiotic sensitivity to levofloxacin was moderate in the PICU and CICU, but mild (
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.792282