Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice

Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2015-12, Vol.21 (1), p.E7-E7
Main Authors: Zhang, Yan, Wu, Liying, Ma, Zhongsu, Cheng, Jia, Liu, Jingbo
Format: Article
Language:English
Subjects:
Animals
anti-diabetic
anti-hyperlipidemic
anti-oxidant
Antidiabetics
Antioxidants
Antioxidants - administration & dosage
Antioxidants - pharmacology
Blood Glucose - drug effects
Body Weight - drug effects
Cholesterol
corn silk
Diabetes
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diuretics
Drinking - drug effects
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - pharmacology
Eating - drug effects
Flavonoids
Flavonoids - administration & dosage
Flavonoids - pharmacology
Herbal medicine
Hyperglycemia
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypolipidemic Agents - administration & dosage
Hypolipidemic Agents - pharmacology
Insulin
Lipids
Metabolism
Mice
Oxidative stress
Streptozocin
Weight control
Zea mays - chemistry
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Summary:Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21010007