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Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice
Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The...
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| Published in: | Molecules (Basel, Switzerland) Switzerland), 2015-12, Vol.21 (1), p.E7-E7 |
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| creator | Zhang, Yan Wu, Liying Ma, Zhongsu Cheng, Jia Liu, Jingbo |
| description | Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions. |
| doi_str_mv | 10.3390/molecules21010007 |
| format | article |
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This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules21010007</identifier><identifier>PMID: 26703560</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; anti-diabetic ; anti-hyperlipidemic ; anti-oxidant ; Antidiabetics ; Antioxidants ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Blood Glucose - drug effects ; Body Weight - drug effects ; Cholesterol ; corn silk ; Diabetes ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diuretics ; Drinking - drug effects ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacology ; Eating - drug effects ; Flavonoids ; Flavonoids - administration & dosage ; Flavonoids - pharmacology ; Herbal medicine ; Hyperglycemia ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Hypolipidemic Agents - administration & dosage ; Hypolipidemic Agents - pharmacology ; Insulin ; Lipids ; Metabolism ; Mice ; Oxidative stress ; Streptozocin ; Weight control ; Zea mays - chemistry</subject><ispartof>Molecules (Basel, Switzerland), 2015-12, Vol.21 (1), p.E7-E7</ispartof><rights>Copyright MDPI AG 2016</rights><rights>2015 by the authors. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-a32bcd25c08fdf3ed658596c73350b439fd67367779c0a90fe669f3a060c0cca3</citedby><cites>FETCH-LOGICAL-c493t-a32bcd25c08fdf3ed658596c73350b439fd67367779c0a90fe669f3a060c0cca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1764370881/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1764370881?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26703560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wu, Liying</creatorcontrib><creatorcontrib>Ma, Zhongsu</creatorcontrib><creatorcontrib>Cheng, Jia</creatorcontrib><creatorcontrib>Liu, Jingbo</creatorcontrib><title>Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions.</description><subject>Animals</subject><subject>anti-diabetic</subject><subject>anti-hyperlipidemic</subject><subject>anti-oxidant</subject><subject>Antidiabetics</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Blood Glucose - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Cholesterol</subject><subject>corn silk</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diuretics</subject><subject>Drinking - drug effects</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Eating - drug effects</subject><subject>Flavonoids</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - pharmacology</subject><subject>Herbal medicine</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - administration & dosage</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Insulin</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Oxidative stress</subject><subject>Streptozocin</subject><subject>Weight control</subject><subject>Zea mays - chemistry</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNplUk1v1DAQjRCItgs_gAuyxIUDgfFH7PiCtFooXamoB8qFi-X4o3hx4q2drNp_39BtqxZO4xm_eTNv9KrqDYaPlEr41KfozBRdIRgwAIhn1SFmBGoKTD5_9D6ojkrZABDMcPOyOiBcAG04HFZXy2EM9ZegOzcG8wHdpmdXwephRHqw-8LJ9dblGLbBuj4YtDRj2IUxuIKSR8dR79KQgi3I59SjVcoD-hHiH5TmeP6rXg92Ms6i-ynoezDuVfXC61jc67u4qH4efz1fndSnZ9_Wq-VpbZikY60p6YwljYHWW0-d5U3bSG4EpQ10jEpvuaBcCCENaAnecS491cDBgDGaLqr1ntcmvVHbHHqdr1XSQd0WUr5QOs9LRaeYE11LWEcbKhiDVreCWC-NaQSnmDcz1-c913bqemeNG8as4xPSpz9D-K0u0k5xIkg761lU7-8IcrqcXBlVH4pxMerBpakoLBosJZ_lzNB3_0A3acrDfKoZxRkV0LZ4RuE9yuRUSnb-YRkM6q9H1H8emXvePlbx0HFvCnoDroi5ag</recordid><startdate>20151223</startdate><enddate>20151223</enddate><creator>Zhang, Yan</creator><creator>Wu, Liying</creator><creator>Ma, Zhongsu</creator><creator>Cheng, Jia</creator><creator>Liu, Jingbo</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151223</creationdate><title>Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice</title><author>Zhang, Yan ; Wu, Liying ; Ma, Zhongsu ; Cheng, Jia ; Liu, Jingbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-a32bcd25c08fdf3ed658596c73350b439fd67367779c0a90fe669f3a060c0cca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>anti-diabetic</topic><topic>anti-hyperlipidemic</topic><topic>anti-oxidant</topic><topic>Antidiabetics</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Blood Glucose - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Cholesterol</topic><topic>corn silk</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diuretics</topic><topic>Drinking - drug effects</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Eating - drug effects</topic><topic>Flavonoids</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - pharmacology</topic><topic>Herbal medicine</topic><topic>Hyperglycemia</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - administration & dosage</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Insulin</topic><topic>Lipids</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Oxidative stress</topic><topic>Streptozocin</topic><topic>Weight control</topic><topic>Zea mays - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wu, Liying</creatorcontrib><creatorcontrib>Ma, Zhongsu</creatorcontrib><creatorcontrib>Cheng, Jia</creatorcontrib><creatorcontrib>Liu, Jingbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yan</au><au>Wu, Liying</au><au>Ma, Zhongsu</au><au>Cheng, Jia</au><au>Liu, Jingbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2015-12-23</date><risdate>2015</risdate><volume>21</volume><issue>1</issue><spage>E7</spage><epage>E7</epage><pages>E7-E7</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>26703560</pmid><doi>10.3390/molecules21010007</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals anti-diabetic anti-hyperlipidemic anti-oxidant Antidiabetics Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Blood Glucose - drug effects Body Weight - drug effects Cholesterol corn silk Diabetes Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diuretics Drinking - drug effects Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Eating - drug effects Flavonoids Flavonoids - administration & dosage Flavonoids - pharmacology Herbal medicine Hyperglycemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Hypolipidemic Agents - administration & dosage Hypolipidemic Agents - pharmacology Insulin Lipids Metabolism Mice Oxidative stress Streptozocin Weight control Zea mays - chemistry |
| title | Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice |
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