Rapid molecular assays for detection of tuberculosis

Tuberculosis (TB) is an infectious disease that remains an important public health problem at the global level. It is one of the main causes of morbidity and mortality, due to the emergence of antibiotic resistant strains and HIV co-infection. Over the past decade, important progress has been made f...

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Bibliographic Details
Published in:Pneumonia 2018-05, Vol.10 (1), p.4-4, Article 4
Main Authors: Eddabra, Rkia, Ait Benhassou, Hassan
Format: Article
Language:English
Subjects:
Acids
Diagnosis
Diagnostic tests
Drug resistance
FDA approval
Genes
HIV
Human immunodeficiency virus
Laboratories
M. Tuberculosis
Microscopy
Nucleic acid amplification tests
Polymerase chain reaction
Review
Sensitivity
Specificity
Tuberculosis
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Summary:Tuberculosis (TB) is an infectious disease that remains an important public health problem at the global level. It is one of the main causes of morbidity and mortality, due to the emergence of antibiotic resistant strains and HIV co-infection. Over the past decade, important progress has been made for better control of the disease. While microscopy and culture continue to be indispensible for laboratory diagnosis of tuberculosis, the range of several molecular diagnostic tests, including the nucleic acid amplification test (NAAT) and whole-genome sequencing (WGS), have expanded tremendously. They are becoming more accessible not only for detection and identification of complex in clinical specimens, but now extend to diagnosing multi-drug resistant strains. Molecular diagnostic tests provide timely results useful for high-quality patient care, low contamination risk, and ease of performance and speed. This review focuses on the current diagnostic tests in use, including emerging technologies used for detection of tuberculosis in clinical specimens. The sensitivity and specificity of these tests have also been taken into consideration.
ISSN:2200-6133
2200-6133
DOI:10.1186/s41479-018-0049-2