Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis

BackgroundObesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thromb...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2022-07, Vol.9, p.906483-906483
Main Authors: Amadio, Patrizia, Macchi, Chiara, Favero, Chiara, Zarà, Marta, Solazzo, Giulia, Dioni, Laura, Sandrini, Leonardo, Vigna, Luisella, Greco, Maria Francesca, Buoli, Massimiliano, Sirtori, Cesare R., Pesatori, Angela Cecilia, Ieraci, Alessandro, Ruscica, Massimiliano, Barbieri, Silvia Stella, Bollati, Valentina
Format: Article
Language:English
Subjects:
atherothrombosis
BDNF
cardiovascular disease
Cardiovascular Medicine
depression
EV-miRNA
obesity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundObesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs. Research ProcessAssociations among circulating BDNF, depression and EV-derived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score. ResultsBDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-γ. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.906483