Transcribed-Ultra Conserved Region expression is associated with outcome in high-risk neuroblastoma

Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, with long-term survival still less than 40%. Hereby, we evaluated the potential of non-coding RNA expres...

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Bibliographic Details
Published in:BMC cancer 2009-12, Vol.9 (1), p.441-441, Article 441
Main Authors: Scaruffi, Paola, Stigliani, Sara, Moretti, Stefano, Coco, Simona, De Vecchi, Carla, Valdora, Francesca, Garaventa, Alberto, Bonassi, Stefano, Tonini, Gian Paolo
Format: Article
Language:English
Subjects:
Base Sequence
Cancer
Care and treatment
Child, Preschool
Conserved Sequence
Development and progression
Gene Expression Regulation, Neoplastic
Genetic aspects
Humans
MicroRNAs - genetics
Neoplasm Staging
Neuroblastoma
Neuroblastoma - genetics
Neuroblastoma - pathology
Neuroblastoma - therapy
Patient outcomes
Physiological aspects
Pilot Projects
Risk Factors
RNA
Transcription, Genetic
Treatment Outcome
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Summary:Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, with long-term survival still less than 40%. Hereby, we evaluated the potential of non-coding RNA expression to predict outcome in high-risk, stage 4 neuroblastoma. We analyzed expression of 481 Ultra Conserved Regions (UCRs) by reverse transcription-quantitative real-time PCR and of 723 microRNAs by microarrays in 34 high-risk, stage 4 neuroblastoma patients. First, the comparison of 8 short- versus 12 long-term survivors showed that 54 UCRs were significantly (P < 0.0491) over-expressed in the former group. For 48 Ultra Conserved Region (UCRs) the expression levels above the cut-off values defined by ROC curves were strongly associated with good-outcome (OS: 0.0001
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-9-441