The antifungal activity of vapour phase of odourless thymol derivate

Thymol is a substance with a great therapeutic potential possessing antibacterial and antifungal activity, with a characteristic odour that remains long after application but is not pleasant at higher concentrations. In this study, attention has been focused on describing the chemical and biological...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2020-08, Vol.8, p.e9601, Article e9601
Main Authors: Kubinec, Róbert, Blaško, Jaroslav, Galbavá, Paulína, Jurdáková, Helena, Sadecká, Jana, Pangallo, Domenico, Bučková, Mária, Puškárová, Andrea
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal agents
Archives & records
Biochemistry
Biological activity
Chromatography
Contamination
Cultural heritage
Deoxyribonucleic acid
DNA
Ecotoxicology
Fungi
Gas chromatography
Health aspects
Mass spectrometry
Microbiology
Mold
Mycology
Odor
Olfactometry
Phenols
Phenols (Class of compounds)
Scientific imaging
Sensors
Thymol
Trimethylsilyl ether of thymol
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Summary:Thymol is a substance with a great therapeutic potential possessing antibacterial and antifungal activity, with a characteristic odour that remains long after application but is not pleasant at higher concentrations. In this study, attention has been focused on describing the chemical and biological properties of the simply prepared trimethylsilyl ether of thymol (kubicin). Interestingly, kubicin has similar volatility as thymol, undergoes hydrolysis in the water (moisture; forming thymol and trimethylsilanol) and can be used at 6,000 times higher concentration than thymol without any negative and irritating odour. Kubicin showed diverse fungistatic and fungicidal activities when tested by direct contact assay, or in vapour phase. The volatile vapour of kubicin was effective on all tested fungal strains. These results suggest that vapours of kubicin might provide an alternative way to fight against fungal contamination.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.9601