Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

• Published in: International journal of molecular sciences 2022-12, Vol.23 (23), p.15222
• Main Authors: Buglak, Andrey A, Kapitonova, Marina A, Vechtomova, Yulia L, Telegina, Taisiya A
• Format: Article
• Language: English
• Subjects: Bacteria; Biochemistry; Biomarkers; Biomedical materials; Biosynthesis; coenzymes; Coenzymes - metabolism; Cofactors; computational chemistry; Cyanobacteria; Electronic structure; Enzymes; Fluorescence; Intermediates; Metabolism; Metalloproteins - metabolism; Molecular Structure; Molybdenum; Organisms; Oxidation; Oxidation-Reduction; Phenylketonuria; Photon absorption; Photonics; Photons; Photoreceptors; photosensitization; Physical chemistry; Proteins; pteridines; Pteridines - chemistry; Pterins - metabolism; Radiation; Raman spectroscopy; Review; Ultraviolet radiation
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms232315222

Pterins are an inseparable part of living organisms. Pterins participate in metabolic reactions mostly as tetrahydropterins. Dihydropterins are usually intermediates of these reactions, whereas oxidized pterins can be biomarkers of diseases. In this review, we analyze the available data on the quantum chemistry of unconjugated pterins as well as their photonics. This gives a comprehensive overview about the electronic structure of pterins and offers some benefits for biomedicine applications: (1) one can affect the enzymatic reactions of aromatic amino acid hydroxylases, NO synthases, and alkylglycerol monooxygenase through UV irradiation of H pterins since UV provokes electron donor reactions of H pterins; (2) the emission properties of H pterins and oxidized pterins can be used in fluorescence diagnostics; (3) two-photon absorption (TPA) should be used in such pterin-related infrared therapy because single-photon absorption in the UV range is inefficient and scatters in vivo; (4) one can affect pathogen organisms through TPA excitation of H pterin cofactors, such as the molybdenum cofactor, leading to its detachment from proteins and subsequent oxidation; (5) metal nanostructures can be used for the UV-vis, fluorescence, and Raman spectroscopy detection of pterin biomarkers. Therefore, we investigated both the biochemistry and physical chemistry of pterins and suggested some potential prospects for pterin-related biomedicine.