Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery

We aimed to evaluate the ability of Adult Comorbidity Evaluation 27 (ACE-27) to predict perioperative outcomes and survival in elderly women with advanced epithelial ovarian cancer (AEOC) undergoing cytoreductive surgery. We collected patients with AEOC in our hospital between January 1, 2012 and Ja...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medical research 2024-03, Vol.29 (1), p.179-179, Article 179
Main Authors: Zhao, Mengna, Gao, Yang, Yang, Junyuan, He, Hao, Su, Min, Wan, Shimeng, Feng, Xiaoye, Wang, Hua, Cai, Hongbing
Format: Article
Language:English
Subjects:
ACE-27
Adult
Age
Aged
Aged patients
Analysis
Cancer therapies
Carcinoma, Ovarian Epithelial - pathology
Carcinoma, Ovarian Epithelial - surgery
Cardiac arrhythmia
Cardiovascular disease
Chemotherapy
Comorbidity
Complications and side effects
Cytoreduction Surgical Procedures
Elderly
Female
Forecasts and trends
Heart failure
Humans
Intensive care
Medical prognosis
Medical records
Medical research
Medicine, Experimental
Older people
Ovarian cancer
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Patients
Prognosis
Retrospective Studies
Risk factors
Statistical analysis
Surgery
Surgical outcomes
Survival analysis
Treatment Outcome
Womens health
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to evaluate the ability of Adult Comorbidity Evaluation 27 (ACE-27) to predict perioperative outcomes and survival in elderly women with advanced epithelial ovarian cancer (AEOC) undergoing cytoreductive surgery. We collected patients with AEOC in our hospital between January 1, 2012 and January 1, 2021. Patients younger than 65 years old or those with non-epithelial ovarian cancer were excluded. ACE-27 was applied retrospectively to assess comorbidities in the selected patients, who were then classified into two groups based on their ACE-27 scores: low ACE-27 score group (none to mild) and high ACE-27 score group (moderate to severe). A total of 222 elderly women with AEOC were included, of whom 164 patients accepted debulking surgery. Among those who have undergone surgery, Clavien-Dindo grade III + perioperative complications or unintended intensive care unit (ICU) admission occurred more often in patients of high ACE-27 score group, with statistically significant difference (odds ratio [OR]: 4.21, 95% confidence interval [CI], 1.28-14.35, p = 0.018). Further stratified analyses by age, BMI, FIGO stage and pathology also prove that OS of patients graded severe was shorter than patients graded none to moderate in cohort of age 
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-024-01666-1