Small-Molecule Targets in Tumor Immunotherapy

Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success o...

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Bibliographic Details
Published in:Natural products and bioprospecting 2018-08, Vol.8 (4), p.297-301
Main Authors: Zhu, Hui-Fang, Li, Yan
Format: Article
Language:English
Subjects:
Antibodies
Biomedical and Life Sciences
Bioorganic Chemistry
Cancer
Cancer immunotherapy
Clinical trials
CTLA-4 protein
Food Science
IDO1
Immune checkpoint
Immune system
Immunogenicity
Immunomodulation
Immunotherapy
Life Sciences
Lymphocytes T
Medicinal Chemistry
Membrane permeability
Molecular chains
Natural products
NKG2DL
PD(L)-1
PD-1 protein
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Receptors
Review
STING
TLRs
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Summary:Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies blockade in advanced stages of cancers has demonstrated the importance of immune modulation. But antibodies-based immunotherapy confronted with some disadvantages, such as immunogenicity, stability, membrane permeability, and production cost. Therefore, alternative approaches including small-molecule-regulated immune response are being introduced. In this review, we focused on some of the key intracellular pathways where small-molecule therapeutic is potential and attractive, which highlights the great potential of natural products in this field.
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-018-0177-7