Advances in Molecular Pathology, Diagnosis and Treatment of Spinal Cord Astrocytomas

Spinal cord astrocytoma (SCA) is a rare subtype of astrocytoma, posing challenges in diagnosis and treatment. Low-grade SCA can achieve long-term survival solely through surgery, while high-grade has a disappointing prognosis even with comprehensive treatment. Diagnostic criteria and standard treatm...

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Bibliographic Details
Published in:Technology in cancer research & treatment 2024-01, Vol.23, p.15330338241262483
Main Authors: Zhao, Zijun, Song, Zihan, Wang, Zairan, Zhang, Fan, Ding, Ze, Fan, Tao
Format: Article
Language:English
Subjects:
Astrocytoma
Astrocytoma - diagnosis
Astrocytoma - genetics
Astrocytoma - pathology
Astrocytoma - therapy
Biomarkers, Tumor - genetics
Diagnosis
Disease Management
DNA damage
DNA Methylation
Humans
Medical diagnosis
Medical prognosis
Molecular modelling
Neoplasm Grading
Pathology
Pathology, Molecular
Prognosis
Radiomics
Review
Spinal cord
Spinal Cord Neoplasms - diagnosis
Spinal Cord Neoplasms - genetics
Spinal Cord Neoplasms - pathology
Spinal Cord Neoplasms - therapy
Tumors
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Summary:Spinal cord astrocytoma (SCA) is a rare subtype of astrocytoma, posing challenges in diagnosis and treatment. Low-grade SCA can achieve long-term survival solely through surgery, while high-grade has a disappointing prognosis even with comprehensive treatment. Diagnostic criteria and standard treatment of intracranial astrocytoma have shown obvious limitations in SCA. Research on the molecular mechanism in SCA is lagging far behind that on intracranial astrocytoma. In recent years, huge breakthroughs have been made in molecular pathology of astrocytoma, and novel techniques have emerged, including DNA methylation analysis and radiomics. These advances are now making it possible to provide a precise diagnosis and develop corresponding treatment strategies in SCA. Our aim is to review the current status of diagnosis and treatment of SCA, and summarize the latest research advancement, including tumor subtype, molecular characteristics, diagnostic technology, and potential therapy strategies, thus deepening our understanding of this uncommon tumor type and providing guidance for accurate diagnosis and treatment.
ISSN:1533-0346
1533-0338
1533-0338
DOI:10.1177/15330338241262483