A systematic discussion and comparison of the construction methods of synthetic microbial community

Synthetic microbial community has widely concerned in the fields of agriculture, food and environment over the past few years. However, there is little consensus on the method to synthetic microbial community from construction to functional verification. Here, we review the concept, characteristics,...

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Bibliographic Details
Published in:Synthetic and systems biotechnology 2024-12, Vol.9 (4), p.775-783
Main Authors: Li, Chenglong, Han, Yanfeng, Zou, Xiao, Zhang, Xueqian, Ran, Qingsong, Dong, Chunbo
Format: Article
Language:English
Subjects:
Adaptability
Agricultural practices
Automation
Community assembly
Construction methods
Core microbiome
Design
Ecosystem biology
Efficiency
Food
Genetic modification
Metabolism
Metabolites
Microbial symbiosis
Microbial technology
Microbiomes
Microbiota
Microorganisms
Plant growth
Pollutants
Reproducibility
Review
Synthetic biology
Synthetic community
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Summary:Synthetic microbial community has widely concerned in the fields of agriculture, food and environment over the past few years. However, there is little consensus on the method to synthetic microbial community from construction to functional verification. Here, we review the concept, characteristics, history and applications of synthetic microbial community, summarizing several methods for synthetic microbial community construction, such as isolation culture, core microbiome mining, automated design, and gene editing. In addition, we also systematically summarized the design concepts, technological thresholds, and applicable scenarios of various construction methods, and highlighted their advantages and limitations. Ultimately, this review provides four efficient, detailed, easy-to-understand and -follow steps for synthetic microbial community construction, with major implications for agricultural practices, food production, and environmental governance.
ISSN:2405-805X
2405-805X
DOI:10.1016/j.synbio.2024.06.006