Prognostic Efficacy of Complete Blood Count Indices for Assessing the Presence and the Progression of Myxomatous Mitral Valve Disease in Dogs

This study investigated the complete blood count (CBC) indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in dogs with myxomatous mitral valve disease (MMVD) and analyzed their correlation with conventional biomarkers,...

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Bibliographic Details
Published in:Animals (Basel) 2023-09, Vol.13 (18), p.2821
Main Authors: Jung, Min-Jung, Kim, Jung-Hyun
Format: Article
Language:English
Subjects:
Biomarkers
Blood diseases
Blood tests
Cardiovascular disease
complete blood count
Development and progression
Dogs
Edema
Ethylenediaminetetraacetic acid
Heart failure
Heart valve diseases
Hematology
Inflammation
Laboratories
Lymphocytes
Medical research
Medicine, Experimental
monocyte-to-lymphocyte ratio
myxomatous mitral valve disease
Natriuretic peptides
neutrophil-to-lymphocyte ratio
platelets-to-lymphocyte ratio
pulmonary edema
Survival analysis
Ultrasonic imaging
Variance analysis
Velocity
Veterinary medicine
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Summary:This study investigated the complete blood count (CBC) indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in dogs with myxomatous mitral valve disease (MMVD) and analyzed their correlation with conventional biomarkers, as well as the effect of CBC indices on survival time in dogs with MMVD. Medical records of 75 healthy controls and 249 dogs with MMVD from March 2015 to October 2022 were analyzed. The NLR, MLR, and PLR were calculated by dividing the absolute counts of the CBC parameters. Dogs with MMVD had significantly higher NLR, MLR, and PLR than healthy dogs (all p < 0.0001), especially those in the symptomatic MMVD group with pulmonary edema (p < 0.0001, p = 0.0002, and p = 0.0387, respectively). The NLR and MLR were significantly correlated with N-terminal pro-B type natriuretic peptide levels (both p < 0.0001). The CBC indices showed potential as biomarkers for detecting the presence of MMVD (all p < 0.0001) and severity of MMVD (p < 0.0001, p < 0.0001, and p = 0.006, respectively) using receiver operating characteristic curve analysis. The negative effects of increased NLR, MLR, and PLR on survival were confirmed using Kaplan–Meier curve analysis. In conclusion, NLR, MLR, and PLR could be cost-effective and readily available potential diagnostic and prognostic biomarkers for MMVD in dogs.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13182821