Conformational Flexibility in Capsids Encoded by the Caliciviridae

Caliciviruses are a diverse group of non-enveloped, positive-sense RNA viruses with a wide range of hosts and transmission routes. Norovirus is the most well-known member of the ; the acute gastroenteritis caused by human norovirus (HuNoV), for example, frequently results in closures of hospital war...

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Bibliographic Details
Published in:Viruses 2024-11, Vol.16 (12), p.1835
Main Authors: Lewis, Charlotte B, Sherry, Lee, Conley, Michaela J, Nakashima, Masaaki, Akbar, Shirin, Govindan, Nithya, Hosie, Margaret J, Bhella, David
Format: Article
Language:English
Subjects:
Animals
Caliciviridae
Caliciviridae - chemistry
Caliciviridae - genetics
Caliciviridae Infections - virology
calicivirus
capsid
Capsid - chemistry
Capsid - metabolism
Capsid protein
Capsid Proteins - chemistry
Capsid Proteins - genetics
Capsid Proteins - metabolism
Capsids
Conformation
cryo-EM
Disease
Disease transmission
Epidemics
Ethylenediaminetetraacetic acid
Flexibility
Gastroenteritis
Gastroenteritis - virology
Genomes
Health aspects
Humans
Immune Evasion
Infections
Marine mammals
Metal ions
Microbiological research
Models, Molecular
Norovirus - chemistry
Norovirus - genetics
P-domain
Physiological aspects
Protein Conformation
Protein structure
Proteins
RNA viruses
structure
Vaccines
Viral proteins
Virulence
Viruses
Citations: Items that this one cites
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Summary:Caliciviruses are a diverse group of non-enveloped, positive-sense RNA viruses with a wide range of hosts and transmission routes. Norovirus is the most well-known member of the ; the acute gastroenteritis caused by human norovirus (HuNoV), for example, frequently results in closures of hospital wards and schools during the winter months. One area of calicivirus biology that has gained increasing attention over the past decade is the conformational flexibility exhibited by the protruding (P) domains of the major capsid protein VP1. This was observed in structure analyses of capsids encoded by many species and is often a consequence of environmental cues such as metal ions, changes to pH, or receptor/co-factor engagement. This review summarises the current understanding of P-domain flexibility, discussing the role this region plays in caliciviral infection and immune evasion, and highlighting potential avenues for further investigation.
ISSN:1999-4915
1999-4915
DOI:10.3390/v16121835