Hepcidin Status in Cord Blood: Observational Data from a Tertiary Institution in Belgium

The hormone hepcidin plays an important role in intestinal iron absorption and cellular release. Cord blood hepcidin values reflect fetal hepcidin status, at least at the time of delivery, but are not available for the Belgian population. Therefore, we aimed (1) to provide the first data on cord blo...

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Bibliographic Details
Published in:Nutrients 2023-01, Vol.15 (3), p.546
Main Authors: Ceulemans, Michael, Van de Vel, Joline, Swinkels, Dorine W, Laarakkers, Coby M M, Billen, Jaak, Van Calsteren, Kristel, Allegaert, Karel
Format: Article
Language:English
Subjects:
Acute phase proteins
Anemia
Belgium
Birth weight
Blood
Body mass index
Cation exchange
Cation exchanging
Chemical properties
Communication
Cord blood
Cross-Sectional Studies
Female
Ferritin
Fetal blood
Fetal Blood - chemistry
Fetuses
Gestational age
Health aspects
Hemoglobin
Hepcidin
Hepcidins
Humans
Iron
Iron in the body
iron regulation
iron status
Mass spectrometry
Mass spectroscopy
Measurement
Medical records
Pediatric research
Peptides
Physiological aspects
Preeclampsia
Pregnancy
Pregnancy complications
Reference materials
Statistical tests
Variables
Womens health
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Summary:The hormone hepcidin plays an important role in intestinal iron absorption and cellular release. Cord blood hepcidin values reflect fetal hepcidin status, at least at the time of delivery, but are not available for the Belgian population. Therefore, we aimed (1) to provide the first data on cord blood hepcidin levels in a Belgian cohort and (2) to determine variables associated with cord blood hepcidin concentrations. A cross-sectional, observational study was performed at the University Hospital Leuven, Belgium. Cord blood samples were analyzed using a combination of weak cation exchange chromatography and time-of-flight mass spectrometry. Descriptive statistics, Spearman correlation tests, and Mann-Whitney U tests were performed. In total, 61 nonhemolyzed cord blood samples were analyzed. The median hepcidin level was 17.6 μg/L (IQR: 18.1; min-max: 3.9-54.7). A moderate correlation was observed between cord blood hepcidin and cord blood ferritin (r = 0.493) and hemoglobin (r = -0.342). Cord blood hepcidin was also associated with mode of delivery ( = 0.01), with higher hepcidin levels for vaginal deliveries. Nonetheless, larger studies are needed to provide more evidence on the actual clinical value and benefit of cord blood hepcidin measurements.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15030546