A database of breast oncogenic specific siRNAs

Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel therapeu...

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Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.8706-6, Article 8706
Main Authors: Tyagi, Atul, Semwal, Manoj, Sharma, Ashok
Format: Article
Language:English
Subjects:
38/77
631/114/129/2043
631/67/1347
Bioinformatics
Breast cancer
Breast Neoplasms - genetics
Cell Line, Tumor
Databases, Genetic
Drug development
Female
Gene Expression Regulation, Neoplastic
Gene silencing
Humanities and Social Sciences
Humans
Internet
multidisciplinary
Oncogenes
RNA, Small Interfering - metabolism
RNA-mediated interference
Science
Science (multidisciplinary)
siRNA
Suppression, Genetic
Tumor cell lines
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Summary:Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel therapeutic strategies for breast cancer. Therefore, identification of such molecules having high oncogene specificity is the need of the hour. Here, we have developed a database named as Breast Oncogenic Specific siRNAs (BOSS, http://bioinformatics.cimap.res.in/sharma/boss/ ) on the basis of the current research status on siRNA-mediated repression of oncogenes in different breast cancer cell lines. BOSS is a resource of experimentally validated breast oncogenic siRNAs, collected from research articles and patents published yet. The present database contains information on 865 breast oncogenic siRNA entries. Each entry provides comprehensive information of an siRNA that includes its name, sequence, target gene, type of cells, and inhibition value, etc. Additionally, some useful tools like siRNAMAP and BOSS BLAST were also developed and linked with the database. siRNAMAP can be used for the selection of best siRNA against a target gene while BOSS BLAST tool helps to locate the siRNA sequences in deferent oncogenes.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-08948-1