Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism

The incidence and mortality of lung cancer are on the rise worldwide. However, the benefit of clinical treatment in lung cancer is limited. Owning to important sources of drug development, natural products have received constant attention around the world. Main ingredient polysaccharides in natural...

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Bibliographic Details
Published in:Pharmacological research 2024-01, Vol.199, p.107034-107034, Article 107034
Main Authors: Tian, Wangqi, Huang, Jumin, Zhang, Weitong, Wang, Yifan, Jin, Ruyi, Guo, Hui, Tang, Yuping, Wang, Yuwei, Lai, Huanling, Leung, Elaine Lai-Han
Format: Article
Language:English
Subjects:
Anti-tumor
Biological Products - pharmacology
Biological Products - therapeutic use
Gastrointestinal Microbiome
Gut microbiota
Humans
Immune system
Lung cancer
Lung Neoplasms - drug therapy
Natural product polysaccharide
Polysaccharides - pharmacology
Polysaccharides - therapeutic use
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Summary:The incidence and mortality of lung cancer are on the rise worldwide. However, the benefit of clinical treatment in lung cancer is limited. Owning to important sources of drug development, natural products have received constant attention around the world. Main ingredient polysaccharides in natural products have been found to have various activities in pharmacological research. In recent years, more and more scientists are looking for the effects and mechanisms of different natural product polysaccharides on lung cancer. In this review, we focus on the following aspects: First, natural product polysaccharides have been discovered to directly suppress the growth of lung cancer cells, which can be effective in limiting tumor progression. Additionally, polysaccharides have been considered to enhance immune function, which can play a pivotal role in fighting lung cancer. Lastly, polysaccharides can improve the efficacy of drugs in lung cancer treatment by regulating the gut microbiota. Overall, the research of natural product polysaccharides in the treatment of lung cancer is a promising area that has the potential to lead to new clinical treatments. With better understanding, natural product polysaccharides have the potential to become important components of future lung cancer treatments.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2023.107034