Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy

• Published in: Journal of cardiothoracic surgery 2021-05, Vol.16 (1), p.133-133, Article 133
• Main Authors: Zhang, Chi, Li, Xiao Kun, Hu, Li Wen, Zheng, Chao, Cong, Zhuang Zhuang, Xu, Yang, Luo, Jing, Wang, Gao Ming, Gu, Wen Feng, Xie, Kai, Luo, Chao, Shen, Yi
• Format: Article
• Language: English
• Subjects: Albumin; Albumins; Anastomotic leak; Anastomotic leakage; Blood; Blood platelets; Body mass index; C-reactive protein; Cancer therapies; Chemotherapy; Complications; Confidence intervals; Diabetes; Esophageal cancer; Esophagectomy; Esophagus; Gastrointestinal surgery; Hemoglobin; Histology; Hospitals; Inflammation; Laboratory tests; Leakage; Lymphocytes; Medical prognosis; Medical research; Medicine, Experimental; Multivariate analysis; Neutrophils; Nutritional status; Patients; Peritonitis; Postoperative period; Proteins; Radiation therapy; Risk analysis; Risk factor; Risk factors; Surgery; Thoracic surgery
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-021-01515-w

Among the many possible postoperative complications, anastomotic leakage (AL) is the most common and serious. Therefore, the purpose of this study was to explore the ability of various inflammatory and nutritional markers to predict postoperative AL in patients after esophagectomy. A total of 273 patients were retrospectively evaluated and enrolled into this study. Perioperative, surgery-related, tumor-related and laboratory tests data were extracted and analyzed. The discriminatory ability and optimal cut-off value was evaluated according to the receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed to access the potential risk factors for AL. The overall incidence of AL was 12.5% (34/273). C-reactive protein-to-albumin ratio (CRP/ALB ratio) [AUC 0.943 (95% confidence interval (CI) = 0.911-0.976, p