Vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma

To describe the evaluation, diagnosis, and treatment of vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma (DLBCL). A 57-year-old woman with a history of non-Hodgkin lymphoma and recent DLBCL relapse presented with frosted branch angiitis tha...

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Bibliographic Details
Published in:American journal of ophthalmology case reports 2023-06, Vol.30, p.101838, Article 101838
Main Authors: Andersen, Tomas, Miller, Charles G., Xia, Tian, Pulido, Jose S., Brucker, Alexander J., Maguire, Albert M.
Format: Article
Language:English
Subjects:
Case Report
Frosted branch angiitis
Intraocular lymphoma
Intravitreal chemotherapy
Optic neuritis
Retinitis
Vitreoretinal lymphoma
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Summary:To describe the evaluation, diagnosis, and treatment of vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma (DLBCL). A 57-year-old woman with a history of non-Hodgkin lymphoma and recent DLBCL relapse presented with frosted branch angiitis that raised suspicion for an infectious retinitis but was found to be vitreoretinal lymphoma. This case primarily highlights the importance of considering vitreoretinal lymphoma on the differential diagnosis of etiologies of frosted branch angiitis. Despite suspicion for vitreoretinal lymphoma, it is also important to treat empirically for infectious etiologies of retinitis in cases of frosted branch angiitis. In this case where the diagnosis was ultimately vitreoretinal lymphoma, weekly alternating intravitreal injections of methotrexate and rituximab led to improvement in visual acuity and retinal infiltration.
ISSN:2451-9936
2451-9936
DOI:10.1016/j.ajoc.2023.101838