A Glance at the Molecules That Regulate Oligodendrocyte Myelination

Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. After demyelination occurs because of pathophysiology, remyelination makes repairs similar to myelination. Proliferation and differentiation are the two main stages in OL myelination,...

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Bibliographic Details
Published in:Current issues in molecular biology 2022-05, Vol.44 (5), p.2194-2216
Main Authors: Wang, Shunqi, Wang, Yingxing, Zou, Suqi
Format: Article
Language:English
Subjects:
differentiation
hypomyelination
maturation
myelination
oligodendrocyte
proliferation
Review
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Summary:Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. After demyelination occurs because of pathophysiology, remyelination makes repairs similar to myelination. Proliferation and differentiation are the two main stages in OL myelination, and most factors commonly play converse roles in these two stages, except for a few factors and signaling pathways, such as OLIG2 (Oligodendrocyte transcription factor 2). Moreover, some OL maturation gene mutations induce hypomyelination or hypermyelination without an obvious function in proliferation and differentiation. Herein, three types of factors regulating myelination are reviewed in sequence.
ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb44050149