Decellularized Extracellular Matrix-Based Bioinks for Tendon Regeneration in Three-Dimensional Bioprinting

In the last few years, attempts to improve the regeneration of damaged tendons have been rising due to the growing demand. However, current treatments to restore the original performance of the tissue focus on the usage of grafts; although, actual grafts are deficient because they often cannot provi...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (21), p.12930
Main Authors: Al-Hakim Khalak, Fouad, García-Villén, Fátima, Ruiz-Alonso, Sandra, Pedraz, José Luis, Saenz-del-Burgo, Laura
Format: Article
Language:English
Subjects:
3-D printers
3D bioprinting
Antigens
Biomaterials
Biomechanics
Biomedical materials
Blood vessels
Bones
Cell growth
Chondroitin sulfate
Collagen
Cytokines
decellularized extracellular matrix
Design
Extracellular matrix
Growth factors
Hyaluronic acid
Injuries
Lasers
Ligaments
Proteins
Regeneration (physiology)
Review
tendon
Tendons
Tissue engineering
Transplants & implants
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Summary:In the last few years, attempts to improve the regeneration of damaged tendons have been rising due to the growing demand. However, current treatments to restore the original performance of the tissue focus on the usage of grafts; although, actual grafts are deficient because they often cannot provide enough support for tissue regeneration, leading to additional complications. The beneficial effect of combining 3D bioprinting and dECM as a novel bioink biomaterial has recently been described. Tendon dECMs have been obtained by using either chemical, biological, or/and physical treatments. Although decellularization protocols are not yet standardized, recently, different protocols have been published. New therapeutic approaches embrace the use of dECM in bioinks for 3D bioprinting, as it has shown promising results in mimicking the composition and the structure of the tissue. However, major obstacles include the poor structural integrity and slow gelation properties of dECM bioinks. Moreover, printing parameters such as speed and temperature have to be optimized for each dECM bioink. Here, we show that dECM bioink for 3D bioprinting provides a promising approach for tendon regeneration for future clinical applications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232112930