Immune Response to Coccidioidomycosis and the Development of a Vaccine

Coccidioidomycosis is a fungal infection caused by and . It is estimated that 150,000 new infections occur in the United States each year. The incidence of this infection continues to rise in endemic regions. There is an urgent need for the development of better therapeutic drugs and a vaccine again...

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Bibliographic Details
Published in:Microorganisms (Basel) 2017-03, Vol.5 (1), p.13
Main Authors: Castro-Lopez, Natalia, Hung, Chiung-Yu
Format: Article
Language:English
Subjects:
Adaptive immunity
Coccidioides
Coccidioides vaccine
coccidioidomycosis
fungal infection
Fungi
Immune response
Immune system
innate immunity
Lymphocytes T
Pathogens
Review
San Joaquin Valley fever
Spherules
T-cell response
Vaccines
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Summary:Coccidioidomycosis is a fungal infection caused by and . It is estimated that 150,000 new infections occur in the United States each year. The incidence of this infection continues to rise in endemic regions. There is an urgent need for the development of better therapeutic drugs and a vaccine against coccidioidomycosis. This review discusses the features of host innate and adaptive immune responses to infection. The focus is on the recent advances in the immune response and host-pathogen interactions, including the recognition of spherules by the host and defining the signal pathways that guide the development of the adaptive T-cell response to infection. Also discussed is an update on progress in developing a vaccine against these fungal pathogens.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms5010013