Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailabil...

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Published in:Pharmaceutics 2022-09, Vol.14 (9), p.1976
Main Authors: Ribeiro, Tais de Cassia, Sábio, Rafael Miguel, Luiz, Marcela Tavares, de Souza, Lucas Canto, Fonseca-Santos, Bruno, Cides da Silva, Luis Carlos, Fantini, Márcia Carvalho de Abreu, Planeta, Cleopatra da Silva, Chorilli, Marlus
Format: Article
Language:English
Subjects:
Adsorption
Alzheimer's disease
Bioavailability
brain disorders
Chemical properties
Colloids
curcuminoids
Drug delivery systems
Drug therapy
Drugs
Ethanol
Health aspects
Hydrogels
mesoporous silica nanoparticles
Nanoparticles
neurodegenerative disorder
Pharmaceutical research
Rheology
Silica
Spectrum analysis
Thermal properties
Turmeric
Vehicles
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Summary:Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailability, besides acting over the main causes associated to AD. A thermo-responsive hydrogel is an interesting approach for facilitating the administration of the nanosystem via a nasal route, as well as for overcoming mucociliary clearance mechanisms. In light of this, MSN-CCM were dispersed in the hydrogel and evaluated through in vitro and in vivo assays. The MSNs and MSN-CCM were successfully characterized by physicochemical analysis and a high value of the CCM encapsulation efficiency (EE%, 87.70 ± 0.05) was achieved. The designed thermo-responsive hydrogel (HG) was characterized by rheology, texture profile analysis, and ex vivo mucoadhesion, showing excellent mechanical and mucoadhesive properties. Ex vivo permeation studies of MSN-CCM and HG@MSN-CCM showed high permeation values (12.46 ± 1.08 and 28.40 ± 1.88 μg cm−2 of CCM, respectively) in porcine nasal mucosa. In vivo studies performed in a streptozotocin-induced AD model confirmed that HG@MSN-CCM reverted the cognitive deficit in mice, acting as a potential formulation in the treatment of AD.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14091976