Considerations for a Reliable In Vitro Model of Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinica...

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Bibliographic Details
Published in:Toxics (Basel) 2021-11, Vol.9 (11), p.300
Main Authors: Eldridge, Sandy, Scuteri, Arianna, Jones, Eugenia, Cavaletti, Guido, Guo, Liang, Glaze, Elizabeth
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor agents
Biocompatibility
Cancer
Cell culture
Chemotherapy
chemotherapy-induced peripheral neuropathy (CIPN)
dorsal root ganglion (DRG)
Drugs
human-induced pluripotent stem cells (hiPSC)
Kinases
Mitochondria
Neurotoxicity
Pathogenesis
Pathophysiology
peripheral neurons
Peripheral neuropathy
Polymerization
Quality of life
Review
Schwann cells
sensory neurons
Toxicity
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Summary:Chemotherapy-induced peripheral neuropathy (CIPN) is widely recognized as a potentially severe toxicity that often leads to dose reduction or discontinuation of cancer treatment. Symptoms may persist despite discontinuation of chemotherapy and quality of life can be severely compromised. The clinical symptoms of CIPN, and the cellular and molecular targets involved in CIPN, are just as diverse as the wide variety of anticancer agents that cause peripheral neurotoxicity. There is an urgent need for extensive molecular and functional investigations aimed at understanding the mechanisms of CIPN. Furthermore, a reliable human cell culture system that recapitulates the diversity of neuronal modalities found in vivo and the pathophysiological changes that underlie CIPN would serve to advance the understanding of the pathogenesis of CIPN. The demonstration of experimental reproducibility in a human peripheral neuronal cell system will increase confidence that such an in vitro model is clinically useful, ultimately resulting in deeper exploration for the prevention and treatment of CIPN. Herein, we review current in vitro models with a focus on key characteristics and attributes desirable for an ideal human cell culture model relevant for CIPN investigations.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics9110300