Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew

: The aim of this study is the synthesis of nanosilver particles (AgNPs) from Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs. : The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration met...

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Published in:Frontiers in bioscience (Landmark. Print) 2021-11, Vol.26 (11), p.1089-1096
Main Authors: Dumlupınar, Berrak, Karatoprak, Gökçe Şeker, Fırat, Mehmet, Akkol, Esra Küpeli
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
antimicrobial
cytotoxicity
geraniaceae
Metal Nanoparticles
Microbial Sensitivity Tests
Pelargonium
pelargonium quercetorum
Plant Extracts - pharmacology
silver nanoparticle
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Summary:: The aim of this study is the synthesis of nanosilver particles (AgNPs) from Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs. : The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay. : The AgNPs inhibited approximately 90% the growth of gram-positive and gram-negative and pathogens at a concentration of 500 μg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 μg/mL. : It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties.
ISSN:2768-6701
2768-6698
DOI:10.52586/5011